Pandemieforschung: von Autoantikörpern und Impfstoff-Innovationen

The study of human antibody repertoires and the underlying mechanisms of diversification are key to understand immune dysregulation, as well as to improve vaccine designs. This article outlines, how the interaction of antibodies and vaccines with body-own structures affects disease pathogenesis and vaccine performance. It is discussed why autoantibodies in COVID-19 should be discriminated in specific-pathogenic versus promiscuous-harmless, and how a strategy called BIBAX improves vaccines by design.