© Pixabay Hübner Lab Genetics and Genomics of Cardiovascular Diseases Profile Team Research Publications News Profile Team Research Publications News Profile Team Group Leader Prof. Dr. Norbert Hübner 87: Timoféeff-Ressovsky-Haus Room: 0.09 nhuebner@mdc-berlin.de +49 30 9406-2530 Scientist Dr. Eleonora Adami Eleonora.Adami@mdc-berlin.de Dr. med. Alena Laschtowitz 87: Timoféeff-Ressovsky-Haus Room: 0.13 Dr. Ning Liang 87: Timoféeff-Ressovsky-Haus Room: 0.10 Ning.Liang@mdc-berlin.de +49 30 9406-4384 Natalia López Anguita 87: Timoféeff-Ressovsky-Haus Room: 0.13 Natalia.LopezAnguita@mdc-berlin.de Dr. Henrike Maatz 87: Timoféeff-Ressovsky-Haus Room: 0.06 h.maatz@mdc-berlin.de +49 30 9406-3037 Dr. Alvaro Perdomo Sabogal Alvaro.Perdomo@mdc-berlin.de Dr. Jorge Ruiz Orera 87: Timoféeff-Ressovsky-Haus Room: 0.17 Jorge.RuizOrera@mdc-berlin.de +49 30 9406-2930 Dr. Kathrin Saar 84: Hermann-von-Helmholtz-Haus Room: 1104 ksaar@mdc-berlin.de +49 30 9406-3534 Secretariat Sabine Meier 87: Timoféeff-Ressovsky-Haus Room: 0.07 Sabine.Meier@mdc-berlin.de +49 30 9406-3512 Technical Assistants Susanne Blachut 87: Timoféeff-Ressovsky-Haus Room: 0.50 s.Blachut@mdc-berlin.de +49 30 9406-3269 Mathias Gerhard 87: Timoféeff-Ressovsky-Haus Room: 0.13 Dr. Giannino Patone 87: Timoféeff-Ressovsky-Haus Room: 0.10 Giannino.Patone@mdc-berlin.de +49 30 9406-3441 Sabine Schmidt 87: Timoféeff-Ressovsky-Haus Room: 0.22 PhD student Nikita Shyam Dewani 87: Timoféeff-Ressovsky-Haus Room: 0.17 Nikita.Dewani@mdc-berlin.de +49 30 9406-3430 Johannes Greiner 87: Timoféeff-Ressovsky-Haus Room: 0.13 Johannes.Greiner@mdc-berlin.de +49 30 9406-2531 Laura Anne Liebig 87: Timoféeff-Ressovsky-Haus Room: 0.13 LauraAnne.Liebig@mdc-berlin.de +49 30 9406-2531 Anna Myronova 87: Timoféeff-Ressovsky-Haus Room: 0.13 Anna.Myronova@mdc-berlin.de +49 30 9406-2531 Nikolay Shvetsov 87: Timoféeff-Ressovsky-Haus Room: 0.13 Nikolay.Shvetsov@mdc-berlin.de +49 30 9406-2531 Research Medical Genomics and Genetics of Cardiovascular and Metabolic Diseases Publications August 05, 2022 / Science Pathogenic variants damage cell composition and single cell transcription in cardiomyopathies D. Reichart E.L. Lindberg H. Maatz A.M.A. Miranda A. Viveiros N. Shvetsov A. Gärtner E.R. Nadelmann M. Lee K. Kanemaru J. Ruiz-Orera V. Strohmenger D.M. DeLaughter G. Patone H. Zhang A. Woehler C. Lippert Y. Kim E. Adami J.M. Gorham S.N. Barnett K. Brown R.J. Buchan R.A. Chowdhury C. Constantinou J. Cranley L.E. Felkin H. Fox A. Ghauri J. Gummert M. Kanda R. Li L. Mach B. McDonough S. Samari F. Shahriaran C. Yapp C. Stanasiuk P.I. Theotokis F.J. Theis A. van den Bogaerdt H. Wakimoto J.S. Ware C.L. Worth P.J.R. Barton Y.A. Lee S.A. Teichmann H. Milting M. Noseda G.Y. Oudit M. Heinig J.G. Seidman N. Hubner C.E. Seidman August 04, 2022 / Mol Cell A high-resolution map of human RNA translation S.P. Chothani E. Adami A.A. Widjaja S.R. Langley S. Viswanathan C.J. Pua N.T. Zhihao N. Harmston G. D'Agostino N. Whiffin W. Mao J.F. Ouyang W.W. Lim S. Lim C.Q.E. Lee A. Grubman J. Chen J.P. Kovalik K. Tryggvason J.M. Polo L. Ho S.A. Cook O.J.L. Rackham S. Schafer July 17, 2022 / Int J Mol Sci In prostate cancer cells cytokines are early responders to gravitational changes occurring in parabolic flights H. Schulz D. Dietrichs M. Wehland T.J. Corydon R. Hemmersbach C. Liemersdorf D. Melnik N. Hübner K. Saar M. Infanger D. Grimm July 12, 2022 / Proc Natl Acad Sci U S A Ablation of lysophosphatidic acid receptor 1 attenuates hypertrophic cardiomyopathy in a mouse model. A. Axelsson Raja H. Wakimoto D.M. DeLaughter D. Reichart J. Gorham D.A. Conner M. Lun C.K. Probst N. Sakai R.S. Knipe S.B. Montesi B. Shea L.P. Adam L.A. Leinwand W. Wan E.S. Choi E.L. Lindberg G. Patone M. Noseda N. Hübner C.E. Seidman A.M. Tager J.G. Seidman C.Y. Ho July 01, 2022 / Nat Biotechnol Standardized annotation of translated open reading frames J.M. Mudge J. Ruiz-Orera J.R. Prensner M.A. Brunet F. Calvet I. Jungreis Jo.M. Gonzalez M. Magrane T.F. Martinez J.F. Schulz Y.T. Yang M.M. Albà J.L. Aspden P.V. Baranov A.A. Bazzini E. Bruford M.J. Martin L. Calviello A.R. Carvunis J. Chen J.P. Couso E.W. Deutsch P. Flicek A. Frankish M. Gerstein N. Hubner N.T. Ingolia M. Kellis G. Menschaert R.L. Moritz U. Ohler X. Roucou A. Saghatelian J.S. Weissman S. van Heesch April 01, 2022 / Life Sci Alliance Cap analysis of gene expression reveals alternative promoter usage in a rat model of hypertension S. Dahale J. Ruiz-Orera J. Silhavy N. Hübner S. van Heesch M. Pravenec S.S. Atanur April 01, 2022 / J Am Soc Nephrol A neutralizing IL-11 antibody improves renal function and increases lifespan in a mouse model of alport syndrome A.A. Widjaja S. Shekeran E. Adami J. Goh J. Tan S. Viswanathan S.Y. Lim P.H. Tan N. Hübner T. Coffman S. Cook March 24, 2022 / Sci Rep Expression of cardiovascular-related microRNAs is altered in L-arginine:glycine amidinotransferase deficient mice M. Jensen C. Müller N. Huebner G. Patone K. Saar C.U. Choe E. Schwedhelm T. Zeller March 24, 2022 / Int J Mol Sci IL11 activates pancreatic stellate cells and causes pancreatic inflammation, fibrosis and atrophy in a mouse model of pancreatitis B. Ng S. Viswanathan A.A. Widjaja W.W. Lim S.G. Shekeran J.W.T. Goh J. Tan F. Kuthubudeen S.Y. Lim C. Xie S. Schafer E. Adami S.A. Cook March 08, 2022 / Sci Rep Naïve-like pluripotency to pave the way for saving the northern white rhinoceros from extinction V. Zywitza E. Rusha D. Shaposhnikov J. Ruiz-Orera N. Telugu V. Rishko M. Hayashi G. Michel L. Wittler J. Stejskal S. Holtze F. Göritz R. Hermes J. Wang Z. Izsvák S. Colleoni G. Lazzari C. Galli T.B. Hildebrandt K. Hayashi S. Diecke M. Drukker Pagination First page « First Previous page ‹‹ … Page 3 Current page 4 Page 5 Page 6 … Next page ›› Last page Last » News Press Release No. 14 June 02, 2014 Berlin How the Environment and Genetics Impact Our DNA Humans have hundreds of different kinds of cells such as blood, kidney, liver or heart cells. All... Science September 16, 2013 By Russell Hodge Hearing a small and quiet chorus in a vast and raucous crowd If you suffer from atopic dermatitis, you surely know it. Infants develop rashes and a susceptibility to allergies that usually persists their whole lives. For years researchers have known that most cases have a hereditary basis, and a few culprit sites have been identified in the human genome. But others have been very difficult to detect. Science June 27, 2012 By Russell Hodge Loosening the springs of the heart Many inbred strains of laboratory rats replicate the complex symptoms found in human diseases and... Press Release No. 10 March 29, 2012 Berlin MDC-Researchers Elucidate Molecular Mechanism Contributing to Severe Forms of Cardiomyopathy Cardiomyopathy comprises a deterioration of the heart muscle that affects the organ's ability to efficiently pump blood through the body. Previously researchers have tied forms of the disease to the alternative splicing of titin, a giant protein that determines the structure and biomechanical properties of the heart, but the molecular mechanism remained unknown. Science June 04, 2010 By Russell Hodge Strokes, madness, and micro-starvation in the brain As people age, they become increasingly prone to strokes and dementia that often lead to death... Science July 16, 2008 By Russell Hodge Partnership between research labs and clinic uncovers heart disease gene Hypertension and heart disease arise through a life-long interaction of hereditary and environmental factors. This complexity has made it hard to discover how individual genes contribute to the development of disease. Press Release No. 12 April 29, 2008 Berlin New Tool Scans the Genome for Disease-relevant Variations Investigating the genetic background of major diseases has now become easier. As part of a European-Japanese Consortium (STAR), Dr. Kathrin Saar and Prof. Norbert Hübner from the MDC Berlin-Buch, Germany, have constructed a genome map with more than 300 different rat strains. The researchers are convinced that this new tool can help understand the development of cardiovascular diseases or diabetes in laboratory rats as well as in humans. The paper of the STAR consortium has been published online in the current issue of the journal Nature Genetics* (Vol. 40, No. 5, pp. 560 – 566, 2008). Press Release No. 11 April 29, 2008 Berlin The Genetic Background of Heart Failure and the Role of Hypertension: A Close Cooperation between Basic Researchers and Clinicians in Berlin-Buch Researchers from Berlin, Germany have identified variations in a gene, which contributes to heart failure in the presence of hypertension. The gene, Ephx2, encodes an enzyme (soluble epoxide hydrolase) that normally degrades specific epoxides. In this case, the epoxides can be cardioprotective in the setting of heart failure but not necessarily relevant for healthy individuals. Science December 03, 2007 By Russell Hodge A wolf on the loose Sometimes the survival of the body calls for the sacrifice of some of its own cells, such as those... Press Release No. 21 September 20, 2007 Berlin Genetic Cause Discovered for Systemic Lupus Erythematosus The exact causes for SLE are still unknown. Triggers are thought to include viruses, the sunlight... Pagination First page « First Previous page ‹‹ Page 1 Page 2 Page 3 Current page 4 Page 5 Next page ›› Last page Last » Prof. Dr. Norbert Hübner Group Leader Contact nhuebner@mdc-berlin.de Phone: +49 30 9406-2530 Max-Delbrück-Centrum für Molekulare Medizin (MDC) Robert-Rössle-Straße 10 13125 Berlin, Deutschland Building 87, Room 0.09 Norbert Hübner is a DZHK Principal Investigator Internal affiliations Genes, Cells and Cell‑based Medicine (topic 1) Research Topics Genetics & Genomics Gene Expression Regulation & RNA Biology Cardiovascular Research
Team Group Leader Prof. Dr. Norbert Hübner 87: Timoféeff-Ressovsky-Haus Room: 0.09 nhuebner@mdc-berlin.de +49 30 9406-2530 Scientist Dr. Eleonora Adami Eleonora.Adami@mdc-berlin.de Dr. med. Alena Laschtowitz 87: Timoféeff-Ressovsky-Haus Room: 0.13 Dr. Ning Liang 87: Timoféeff-Ressovsky-Haus Room: 0.10 Ning.Liang@mdc-berlin.de +49 30 9406-4384 Natalia López Anguita 87: Timoféeff-Ressovsky-Haus Room: 0.13 Natalia.LopezAnguita@mdc-berlin.de Dr. Henrike Maatz 87: Timoféeff-Ressovsky-Haus Room: 0.06 h.maatz@mdc-berlin.de +49 30 9406-3037 Dr. Alvaro Perdomo Sabogal Alvaro.Perdomo@mdc-berlin.de Dr. Jorge Ruiz Orera 87: Timoféeff-Ressovsky-Haus Room: 0.17 Jorge.RuizOrera@mdc-berlin.de +49 30 9406-2930 Dr. Kathrin Saar 84: Hermann-von-Helmholtz-Haus Room: 1104 ksaar@mdc-berlin.de +49 30 9406-3534 Secretariat Sabine Meier 87: Timoféeff-Ressovsky-Haus Room: 0.07 Sabine.Meier@mdc-berlin.de +49 30 9406-3512 Technical Assistants Susanne Blachut 87: Timoféeff-Ressovsky-Haus Room: 0.50 s.Blachut@mdc-berlin.de +49 30 9406-3269 Mathias Gerhard 87: Timoféeff-Ressovsky-Haus Room: 0.13 Dr. Giannino Patone 87: Timoféeff-Ressovsky-Haus Room: 0.10 Giannino.Patone@mdc-berlin.de +49 30 9406-3441 Sabine Schmidt 87: Timoféeff-Ressovsky-Haus Room: 0.22 PhD student Nikita Shyam Dewani 87: Timoféeff-Ressovsky-Haus Room: 0.17 Nikita.Dewani@mdc-berlin.de +49 30 9406-3430 Johannes Greiner 87: Timoféeff-Ressovsky-Haus Room: 0.13 Johannes.Greiner@mdc-berlin.de +49 30 9406-2531 Laura Anne Liebig 87: Timoféeff-Ressovsky-Haus Room: 0.13 LauraAnne.Liebig@mdc-berlin.de +49 30 9406-2531 Anna Myronova 87: Timoféeff-Ressovsky-Haus Room: 0.13 Anna.Myronova@mdc-berlin.de +49 30 9406-2531 Nikolay Shvetsov 87: Timoféeff-Ressovsky-Haus Room: 0.13 Nikolay.Shvetsov@mdc-berlin.de +49 30 9406-2531
Publications August 05, 2022 / Science Pathogenic variants damage cell composition and single cell transcription in cardiomyopathies D. Reichart E.L. Lindberg H. Maatz A.M.A. Miranda A. Viveiros N. Shvetsov A. Gärtner E.R. Nadelmann M. Lee K. Kanemaru J. Ruiz-Orera V. Strohmenger D.M. DeLaughter G. Patone H. Zhang A. Woehler C. Lippert Y. Kim E. Adami J.M. Gorham S.N. Barnett K. Brown R.J. Buchan R.A. Chowdhury C. Constantinou J. Cranley L.E. Felkin H. Fox A. Ghauri J. Gummert M. Kanda R. Li L. Mach B. McDonough S. Samari F. Shahriaran C. Yapp C. Stanasiuk P.I. Theotokis F.J. Theis A. van den Bogaerdt H. Wakimoto J.S. Ware C.L. Worth P.J.R. Barton Y.A. Lee S.A. Teichmann H. Milting M. Noseda G.Y. Oudit M. Heinig J.G. Seidman N. Hubner C.E. Seidman August 04, 2022 / Mol Cell A high-resolution map of human RNA translation S.P. Chothani E. Adami A.A. Widjaja S.R. Langley S. Viswanathan C.J. Pua N.T. Zhihao N. Harmston G. D'Agostino N. Whiffin W. Mao J.F. Ouyang W.W. Lim S. Lim C.Q.E. Lee A. Grubman J. Chen J.P. Kovalik K. Tryggvason J.M. Polo L. Ho S.A. Cook O.J.L. Rackham S. Schafer July 17, 2022 / Int J Mol Sci In prostate cancer cells cytokines are early responders to gravitational changes occurring in parabolic flights H. Schulz D. Dietrichs M. Wehland T.J. Corydon R. Hemmersbach C. Liemersdorf D. Melnik N. Hübner K. Saar M. Infanger D. Grimm July 12, 2022 / Proc Natl Acad Sci U S A Ablation of lysophosphatidic acid receptor 1 attenuates hypertrophic cardiomyopathy in a mouse model. A. Axelsson Raja H. Wakimoto D.M. DeLaughter D. Reichart J. Gorham D.A. Conner M. Lun C.K. Probst N. Sakai R.S. Knipe S.B. Montesi B. Shea L.P. Adam L.A. Leinwand W. Wan E.S. Choi E.L. Lindberg G. Patone M. Noseda N. Hübner C.E. Seidman A.M. Tager J.G. Seidman C.Y. Ho July 01, 2022 / Nat Biotechnol Standardized annotation of translated open reading frames J.M. Mudge J. Ruiz-Orera J.R. Prensner M.A. Brunet F. Calvet I. Jungreis Jo.M. Gonzalez M. Magrane T.F. Martinez J.F. Schulz Y.T. Yang M.M. Albà J.L. Aspden P.V. Baranov A.A. Bazzini E. Bruford M.J. Martin L. Calviello A.R. Carvunis J. Chen J.P. Couso E.W. Deutsch P. Flicek A. Frankish M. Gerstein N. Hubner N.T. Ingolia M. Kellis G. Menschaert R.L. Moritz U. Ohler X. Roucou A. Saghatelian J.S. Weissman S. van Heesch April 01, 2022 / Life Sci Alliance Cap analysis of gene expression reveals alternative promoter usage in a rat model of hypertension S. Dahale J. Ruiz-Orera J. Silhavy N. Hübner S. van Heesch M. Pravenec S.S. Atanur April 01, 2022 / J Am Soc Nephrol A neutralizing IL-11 antibody improves renal function and increases lifespan in a mouse model of alport syndrome A.A. Widjaja S. Shekeran E. Adami J. Goh J. Tan S. Viswanathan S.Y. Lim P.H. Tan N. Hübner T. Coffman S. Cook March 24, 2022 / Sci Rep Expression of cardiovascular-related microRNAs is altered in L-arginine:glycine amidinotransferase deficient mice M. Jensen C. Müller N. Huebner G. Patone K. Saar C.U. Choe E. Schwedhelm T. Zeller March 24, 2022 / Int J Mol Sci IL11 activates pancreatic stellate cells and causes pancreatic inflammation, fibrosis and atrophy in a mouse model of pancreatitis B. Ng S. Viswanathan A.A. Widjaja W.W. Lim S.G. Shekeran J.W.T. Goh J. Tan F. Kuthubudeen S.Y. Lim C. Xie S. Schafer E. Adami S.A. Cook March 08, 2022 / Sci Rep Naïve-like pluripotency to pave the way for saving the northern white rhinoceros from extinction V. Zywitza E. Rusha D. Shaposhnikov J. Ruiz-Orera N. Telugu V. Rishko M. Hayashi G. Michel L. Wittler J. Stejskal S. Holtze F. Göritz R. Hermes J. Wang Z. Izsvák S. Colleoni G. Lazzari C. Galli T.B. Hildebrandt K. Hayashi S. Diecke M. Drukker Pagination First page « First Previous page ‹‹ … Page 3 Current page 4 Page 5 Page 6 … Next page ›› Last page Last »
August 05, 2022 / Science Pathogenic variants damage cell composition and single cell transcription in cardiomyopathies D. Reichart E.L. Lindberg H. Maatz A.M.A. Miranda A. Viveiros N. Shvetsov A. Gärtner E.R. Nadelmann M. Lee K. Kanemaru J. Ruiz-Orera V. Strohmenger D.M. DeLaughter G. Patone H. Zhang A. Woehler C. Lippert Y. Kim E. Adami J.M. Gorham S.N. Barnett K. Brown R.J. Buchan R.A. Chowdhury C. Constantinou J. Cranley L.E. Felkin H. Fox A. Ghauri J. Gummert M. Kanda R. Li L. Mach B. McDonough S. Samari F. Shahriaran C. Yapp C. Stanasiuk P.I. Theotokis F.J. Theis A. van den Bogaerdt H. Wakimoto J.S. Ware C.L. Worth P.J.R. Barton Y.A. Lee S.A. Teichmann H. Milting M. Noseda G.Y. Oudit M. Heinig J.G. Seidman N. Hubner C.E. Seidman
August 04, 2022 / Mol Cell A high-resolution map of human RNA translation S.P. Chothani E. Adami A.A. Widjaja S.R. Langley S. Viswanathan C.J. Pua N.T. Zhihao N. Harmston G. D'Agostino N. Whiffin W. Mao J.F. Ouyang W.W. Lim S. Lim C.Q.E. Lee A. Grubman J. Chen J.P. Kovalik K. Tryggvason J.M. Polo L. Ho S.A. Cook O.J.L. Rackham S. Schafer
July 17, 2022 / Int J Mol Sci In prostate cancer cells cytokines are early responders to gravitational changes occurring in parabolic flights H. Schulz D. Dietrichs M. Wehland T.J. Corydon R. Hemmersbach C. Liemersdorf D. Melnik N. Hübner K. Saar M. Infanger D. Grimm
July 12, 2022 / Proc Natl Acad Sci U S A Ablation of lysophosphatidic acid receptor 1 attenuates hypertrophic cardiomyopathy in a mouse model. A. Axelsson Raja H. Wakimoto D.M. DeLaughter D. Reichart J. Gorham D.A. Conner M. Lun C.K. Probst N. Sakai R.S. Knipe S.B. Montesi B. Shea L.P. Adam L.A. Leinwand W. Wan E.S. Choi E.L. Lindberg G. Patone M. Noseda N. Hübner C.E. Seidman A.M. Tager J.G. Seidman C.Y. Ho
July 01, 2022 / Nat Biotechnol Standardized annotation of translated open reading frames J.M. Mudge J. Ruiz-Orera J.R. Prensner M.A. Brunet F. Calvet I. Jungreis Jo.M. Gonzalez M. Magrane T.F. Martinez J.F. Schulz Y.T. Yang M.M. Albà J.L. Aspden P.V. Baranov A.A. Bazzini E. Bruford M.J. Martin L. Calviello A.R. Carvunis J. Chen J.P. Couso E.W. Deutsch P. Flicek A. Frankish M. Gerstein N. Hubner N.T. Ingolia M. Kellis G. Menschaert R.L. Moritz U. Ohler X. Roucou A. Saghatelian J.S. Weissman S. van Heesch
April 01, 2022 / Life Sci Alliance Cap analysis of gene expression reveals alternative promoter usage in a rat model of hypertension S. Dahale J. Ruiz-Orera J. Silhavy N. Hübner S. van Heesch M. Pravenec S.S. Atanur
April 01, 2022 / J Am Soc Nephrol A neutralizing IL-11 antibody improves renal function and increases lifespan in a mouse model of alport syndrome A.A. Widjaja S. Shekeran E. Adami J. Goh J. Tan S. Viswanathan S.Y. Lim P.H. Tan N. Hübner T. Coffman S. Cook
March 24, 2022 / Sci Rep Expression of cardiovascular-related microRNAs is altered in L-arginine:glycine amidinotransferase deficient mice M. Jensen C. Müller N. Huebner G. Patone K. Saar C.U. Choe E. Schwedhelm T. Zeller
March 24, 2022 / Int J Mol Sci IL11 activates pancreatic stellate cells and causes pancreatic inflammation, fibrosis and atrophy in a mouse model of pancreatitis B. Ng S. Viswanathan A.A. Widjaja W.W. Lim S.G. Shekeran J.W.T. Goh J. Tan F. Kuthubudeen S.Y. Lim C. Xie S. Schafer E. Adami S.A. Cook
March 08, 2022 / Sci Rep Naïve-like pluripotency to pave the way for saving the northern white rhinoceros from extinction V. Zywitza E. Rusha D. Shaposhnikov J. Ruiz-Orera N. Telugu V. Rishko M. Hayashi G. Michel L. Wittler J. Stejskal S. Holtze F. Göritz R. Hermes J. Wang Z. Izsvák S. Colleoni G. Lazzari C. Galli T.B. Hildebrandt K. Hayashi S. Diecke M. Drukker
News Press Release No. 14 June 02, 2014 Berlin How the Environment and Genetics Impact Our DNA Humans have hundreds of different kinds of cells such as blood, kidney, liver or heart cells. All... Science September 16, 2013 By Russell Hodge Hearing a small and quiet chorus in a vast and raucous crowd If you suffer from atopic dermatitis, you surely know it. Infants develop rashes and a susceptibility to allergies that usually persists their whole lives. For years researchers have known that most cases have a hereditary basis, and a few culprit sites have been identified in the human genome. But others have been very difficult to detect. Science June 27, 2012 By Russell Hodge Loosening the springs of the heart Many inbred strains of laboratory rats replicate the complex symptoms found in human diseases and... Press Release No. 10 March 29, 2012 Berlin MDC-Researchers Elucidate Molecular Mechanism Contributing to Severe Forms of Cardiomyopathy Cardiomyopathy comprises a deterioration of the heart muscle that affects the organ's ability to efficiently pump blood through the body. Previously researchers have tied forms of the disease to the alternative splicing of titin, a giant protein that determines the structure and biomechanical properties of the heart, but the molecular mechanism remained unknown. Science June 04, 2010 By Russell Hodge Strokes, madness, and micro-starvation in the brain As people age, they become increasingly prone to strokes and dementia that often lead to death... Science July 16, 2008 By Russell Hodge Partnership between research labs and clinic uncovers heart disease gene Hypertension and heart disease arise through a life-long interaction of hereditary and environmental factors. This complexity has made it hard to discover how individual genes contribute to the development of disease. Press Release No. 12 April 29, 2008 Berlin New Tool Scans the Genome for Disease-relevant Variations Investigating the genetic background of major diseases has now become easier. As part of a European-Japanese Consortium (STAR), Dr. Kathrin Saar and Prof. Norbert Hübner from the MDC Berlin-Buch, Germany, have constructed a genome map with more than 300 different rat strains. The researchers are convinced that this new tool can help understand the development of cardiovascular diseases or diabetes in laboratory rats as well as in humans. The paper of the STAR consortium has been published online in the current issue of the journal Nature Genetics* (Vol. 40, No. 5, pp. 560 – 566, 2008). Press Release No. 11 April 29, 2008 Berlin The Genetic Background of Heart Failure and the Role of Hypertension: A Close Cooperation between Basic Researchers and Clinicians in Berlin-Buch Researchers from Berlin, Germany have identified variations in a gene, which contributes to heart failure in the presence of hypertension. The gene, Ephx2, encodes an enzyme (soluble epoxide hydrolase) that normally degrades specific epoxides. In this case, the epoxides can be cardioprotective in the setting of heart failure but not necessarily relevant for healthy individuals. Science December 03, 2007 By Russell Hodge A wolf on the loose Sometimes the survival of the body calls for the sacrifice of some of its own cells, such as those... Press Release No. 21 September 20, 2007 Berlin Genetic Cause Discovered for Systemic Lupus Erythematosus The exact causes for SLE are still unknown. Triggers are thought to include viruses, the sunlight... Pagination First page « First Previous page ‹‹ Page 1 Page 2 Page 3 Current page 4 Page 5 Next page ›› Last page Last »
Press Release No. 14 June 02, 2014 Berlin How the Environment and Genetics Impact Our DNA Humans have hundreds of different kinds of cells such as blood, kidney, liver or heart cells. All...
Science September 16, 2013 By Russell Hodge Hearing a small and quiet chorus in a vast and raucous crowd If you suffer from atopic dermatitis, you surely know it. Infants develop rashes and a susceptibility to allergies that usually persists their whole lives. For years researchers have known that most cases have a hereditary basis, and a few culprit sites have been identified in the human genome. But others have been very difficult to detect.
Science June 27, 2012 By Russell Hodge Loosening the springs of the heart Many inbred strains of laboratory rats replicate the complex symptoms found in human diseases and...
Press Release No. 10 March 29, 2012 Berlin MDC-Researchers Elucidate Molecular Mechanism Contributing to Severe Forms of Cardiomyopathy Cardiomyopathy comprises a deterioration of the heart muscle that affects the organ's ability to efficiently pump blood through the body. Previously researchers have tied forms of the disease to the alternative splicing of titin, a giant protein that determines the structure and biomechanical properties of the heart, but the molecular mechanism remained unknown.
Science June 04, 2010 By Russell Hodge Strokes, madness, and micro-starvation in the brain As people age, they become increasingly prone to strokes and dementia that often lead to death...
Science July 16, 2008 By Russell Hodge Partnership between research labs and clinic uncovers heart disease gene Hypertension and heart disease arise through a life-long interaction of hereditary and environmental factors. This complexity has made it hard to discover how individual genes contribute to the development of disease.
Press Release No. 12 April 29, 2008 Berlin New Tool Scans the Genome for Disease-relevant Variations Investigating the genetic background of major diseases has now become easier. As part of a European-Japanese Consortium (STAR), Dr. Kathrin Saar and Prof. Norbert Hübner from the MDC Berlin-Buch, Germany, have constructed a genome map with more than 300 different rat strains. The researchers are convinced that this new tool can help understand the development of cardiovascular diseases or diabetes in laboratory rats as well as in humans. The paper of the STAR consortium has been published online in the current issue of the journal Nature Genetics* (Vol. 40, No. 5, pp. 560 – 566, 2008).
Press Release No. 11 April 29, 2008 Berlin The Genetic Background of Heart Failure and the Role of Hypertension: A Close Cooperation between Basic Researchers and Clinicians in Berlin-Buch Researchers from Berlin, Germany have identified variations in a gene, which contributes to heart failure in the presence of hypertension. The gene, Ephx2, encodes an enzyme (soluble epoxide hydrolase) that normally degrades specific epoxides. In this case, the epoxides can be cardioprotective in the setting of heart failure but not necessarily relevant for healthy individuals.
Science December 03, 2007 By Russell Hodge A wolf on the loose Sometimes the survival of the body calls for the sacrifice of some of its own cells, such as those...
Press Release No. 21 September 20, 2007 Berlin Genetic Cause Discovered for Systemic Lupus Erythematosus The exact causes for SLE are still unknown. Triggers are thought to include viruses, the sunlight...
Prof. Dr. Norbert Hübner Group Leader Contact nhuebner@mdc-berlin.de Phone: +49 30 9406-2530 Max-Delbrück-Centrum für Molekulare Medizin (MDC) Robert-Rössle-Straße 10 13125 Berlin, Deutschland Building 87, Room 0.09 Norbert Hübner is a DZHK Principal Investigator Internal affiliations Genes, Cells and Cell‑based Medicine (topic 1)